Corneal lymphangiogenesis correlates closely with hemangiogenesis after keratoplasty
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National Natural Science Foundation of China (No.30700927); Guangdong Technology Program Foundation, China (No.93068)

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    Abstract:

    AIM: To examine the relationship between corneal lymphangiogenesis and hemangiogenesis after keratoplasty. · METHODS: Nineteen human corneas were obtained from 19 patients undergoing a second corneal transplantation in Zhongshan Ophthalmic Center in 2005. Blood and lymphatic vessels in human transplanted corneas were identified by lymphatic vessel endothelial receptor (LYVE-1) and platelet endothelial cell adhesion modecule-1 (PECAM-1) immunohi- stochemistry, and double enzyme-histochemistry; then the association of corneal blood vessel counting (BVC) with lymphatic vessel counting (LVC) was examined. · RESULTS: Corneal hemangiogenesis was present in 12 cases (63%), and lymphangiogenesis occurred in 5 cases (26%) human transplanted corneas. In addition, corneal lymphangiogenesis was only present in vascularized corneas. LVC was strongly and positively correlated with BVC(r=0.725, P <0.01). · CONCLUSION: Corneal lymphangiogenesis develops after keratoplasty and strongly associates with hemangiogenesis.

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Shi-Qi Ling, Can Liu, Wei-Hua Li, et al. Corneal lymphangiogenesis correlates closely with hemangiogenesis after keratoplasty. Int J Ophthalmol, 2010,3(1):76-79

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