Effect of alloxan time administerDrug on establishing diabetic rabbit model
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This project is subsidized financially by Xi'an Science and Technology Bureau of China (No. YF07142)

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    Abstract:

    AIM: To explore the effect of alloxan time administerDrug on establishing diabetic rabbit model. METHODS: Thirty-six healthy rabbits, weighed 2-2.5kg, were randomly divided into one time administerDrug group (Group A, n=12), two times administerDrug group (Group B, n=12) and three times administerDrug group(Group C, n=12). Every rabbit was injected with alloxan of 150mg/kg. The three groups were measured for fasting blood-glucose. The success rate and death rate of each group were also calculated. RESULTS: The success rate of diabetic rabbit model in Group B was higher than that in Group A (P<0.01) but its death rate was lower than that of Group A (P<0.01); the success rate of diabetic rabbit model in Group C was highest but the death rate was the lowest in the three groups. CONCLUSION: Separate administration of alloxan can improve success rate in establishing diabetic rabbit model, decrease the death rate and keep the stability of model.

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Wen-Tao Sun, Chun-Ling Lei, Chun-Chao Bi, et al. Effect of alloxan time administerDrug on establishing diabetic rabbit model. Int J Ophthalmol, 2010,3(3):200-202

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