Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium
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National Natural Science Foundation of China (No. 81070711); Natural Science Foundation of Guangdong Province, China (No. S2011010006061); Training Program of Young Teachers of Sun Yat-sen University, China (No. 11ykpy42); Program of Low Vision Survey in Guangzhou, China (No A938)

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    Abstract:

    AIM: To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia. METHODS: Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD31 and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined. RESULTS: There was a large number of CD31(+)LYVE-1(-) blood vessels but only a few CD31(+)LYVE-1(+) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia. CONCLUSION: There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.

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Chao-Xiu Qi, Xiao-Dong Zhang, Jin Yuan, et al. Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. Int J Ophthalmol, 2012,5(6):655-660

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Publication History
  • Received:June 29,2012
  • Revised:November 05,2012
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