Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
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Supported by National Natural Science Foundation of China (No.81070753); Natural Science Foundation of Guangdong Province, China (No.10251008901000025)
Conflicts of interest: Li HH, None; Huo LJ, None; Gao ZY, None; Zhao F, None; Zeng JW, None.

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    Abstract:

    Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.

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Hong-Hui Li, Li-Jun Huo, Feng Zhao, et al. Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2. Int J Ophthalmol, 2014,7(1):152-156

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Publication History
  • Received:June 01,2013
  • Revised:October 21,2013
  • Adopted:October 21,2013
  • Online: February 20,2014
  • Published: