Retinopathy in non diabetics, diabetic retinopathy and oxidative stress:a new phenotype in Central Africa?
Author:
Corresponding Author:

Affiliation:

Clc Number:

Fund Project:


Conflicts of Interest: Longo-Mbenza B, None; Mvitu Muaka M, None; Masamba W, None; Muizila Kini L, None; Longo Phemba I, None; Kibokela Ndembe D, None; Tulomba Mona D, None.
ACKNOWLEDGEMENTS: We thank Mr. Simon Stimela Mathabatha in Memoriam, Analytical Chemistry Laboratory from Walter Sisulu University, Mthatha, South Africa and the staff of LOMO Medical Laboratory, Kinshasa, Limete, DRC.

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To evaluate the rates of retinopathy without diabetes and diabetic retinopathy (DR), associated with some markers of oxidative stress, antioxidants and cardiometabolic risk factors.METHODS: We determined the prevalence of DR in 150 type 2 diabetes mellitus (T2DM) patients, that of retinopathy in 50 non diabetics, the levels of body mass index (BMI), waist circumference (WC), blood pressure, lipids, 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), gamma-glutamyl transferase GT (GGT), oxidized low-density lipoprotein (OxLDL), thiobarbituric acid reacting substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), uric acid, creatinine, albumin, total antioxidant status (TAOS), zinc, selenium, magnesium, vitamin C, vitamin D, vitamin E, glucose, apolipoprotein B (ApoB).RESULTS: The prevalences of DR at 53y and Rtp at 62y were 44% (n=66) and 10% (n=5), respectively. The highest levels of 8-isoprostane, 8-OHdG, TBARS, SOD, and OxLDL were in DR. The lowest levels of vitamin D, vitamin C, TAOS, and vitamin E were in DR. In the case-control study discriminant analysis, the levels of vitamin C, vitamin D, ApoB, 8-OHdG, creatinine, Zn, vitamin E, and WC distinguished significantly non-diabetics without DR (controls), T2DM patients without DR and T2DM patients with DR.CONCLUSION: Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2 diabetics. Prevention of oxidative stress and abdominal obesity is needed. Supplementation in vitamin C, D, and E should be recommended as complement therapies of T2DM.

    Reference
    Related
    Cited by
Get Citation

Benjamin Longo-Mbenza, Moise Mvitu Muaka, Wayiza Masamba, et al. Retinopathy in non diabetics, diabetic retinopathy and oxidative stress:a new phenotype in Central Africa?. Int J Ophthalmol, 2014,7(2):293-301

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:August 29,2013
  • Revised:October 14,2013
  • Adopted:October 14,2013
  • Online: April 23,2014
  • Published: