Protective effects of naringenin eye drops on N-methyl-N-nitrosourea-induced photoreceptor cell death in rats
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1School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China;
2Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China;
3Zhuhai United Laboratories Co., Ltd, Zhuhai 519040, Guangdong Province, China

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Supported by Guangdong Provincial Department of Science and Technology Grant (No.2011B031700052).
Conflicts of Interest: Lin JL, None; Wang YD, None; Ma Y, None; Zhong CM, None; Zhu MR, None; Chen WP, None; Lin BQ, None.

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    Abstract:

    AIM: To investigate the effects of naringenin eye drops on N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell death in rats.METHODS: Photoreceptor cell death was induced by single intraperitoneal injection of MNU (60 mg/kg) in rats. Both eyes of all animals were instilled with one drop of vehicle, 0.5% or 1.0% naringenin eye drops three times per day from 7d before to 17d after MNU injection. Effects of naringenin on MNU-induced photoreceptor cell death were evaluated by electrophysiological and histological analysis.RESULTS:Flash electroretinography (FERG) and oscillatory potentials (OPs) recordings showed that the vehicle control group had remarkable reduction of amplitudes and prolongation of latency times. FERG and OPs responses were significantly reversed in MNU-induced rats treated with 0.5% or 1.0% naringenin eye drops compared with the vehicle control. The retinal morphological results showed that naringenin dose-dependently preserved the outer nuclear layer, outer retina and total retina.CONCLUSION:These results indicate that topical treatment with naringenin eye drops prevented retinal neurons from MNU-induced structural and functional damages.

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Jun-Li Lin, Yan-Dong Wang, Yan Ma, et al. Protective effects of naringenin eye drops on N-methyl-N-nitrosourea-induced photoreceptor cell death in rats. Int J Ophthalmol, 2014,7(3):391-396

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Publication History
  • Received:January 09,2014
  • Revised:March 04,2014
  • Adopted:March 04,2014
  • Online: June 24,2014
  • Published: