Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population
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1Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara 06800, Turkey;
2Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya 42131, Turkey;
3Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey

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Supported by Scientific Research Fund of Hacettepe University (No.0401601001).
Conflicts of Interest: Saglar E, None; Bozkurt B, None; Irkec M, None. ACKNOWLEDGEMENTS: The authors thank Prof. Dr. Ay Ogus for her contribution during the experimental stage.

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    Abstract:

    AIM: To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.RESULTS:Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.CONCLUSION: APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.

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Emel Saglar, Banu Bozkurt, Murat Irkec. Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population. Int J Ophthalmol, 2014,7(3):426-430

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Publication History
  • Received:August 06,2013
  • Revised:November 25,2013
  • Adopted:November 25,2013
  • Online: June 24,2014
  • Published: