Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome:one year follow-up results
Author:
Corresponding Author:

Affiliation:

1Department of Ophtalmology, Izmir University Faculty of Medicine, Izmir 35340, Turkey;2Alfagoz Eye Center, Izmir 35330, Turkey

Clc Number:

Fund Project:

None.
Conflicts of Interest: Zengin MO, None; Tuncer I, None; Karahan E, None.

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM:To investigate the retinal nerve fiber layer (RNFL) thickness changes in patients with obstructive sleep apnea syndrome (OSAS) for one year follow-up. To discuss the possibility of detecting tendency of glaucoma in this population by using spectral domain optical coherence tomography (3D-OCT-2000 Spectral domain).METHODS:After polysomnographic study, all subjects (64 OSAS patients and 40 controls) underwent detailed ophthalmological examination. After these examinations, patients with glaucoma and patients who had ophthalmological and/or systemic disease were excluded from the study. Totally, 20 patients in OSAS group and five patients in controls were excluded from the study in the first examination and follow-up period. The RNFL thickness was assessed with OCT. Forty-four OSAS patients and 35 control subjects were followed up 12mo. RNFL thickness change and OSAS patients were evaluated for severity of disease by Apnea-Hypopnea Index (AHI).RESULTS:Forty-four OSAS patients and 35 controls were enrolled in the study. Statistically significance was found between OSAS patients and controls at the 12th mo. Average RNFL thickness was found to be significantly lower in last measurements in OSAS patients when compared with first measurements and control subjects (P<0.001, 0.002, respectively). There was a statistically significant correlation among AHI, and RNFL thickness (P<0.05).CONCLUSION:The results suggest that the patients with OSAS were related with a proportional decrease in the RNFL thickness. These patients should be followed up regularly for glaucomatous changes. Detecting more RNFL thinning in severe OSAS was important.

    Reference
    Related
    Cited by
Get Citation

Mehmet Ozgur Zengin, Ibrahim Tuncer, Eyyup Karahan. Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome:one year follow-up results. Int J Ophthalmol, 2014,7(4):704-708

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:October 25,2013
  • Revised:January 26,2013
  • Adopted:January 26,2013
  • Online: August 15,2014
  • Published: