Meta-analysis of best corrected visual acuity after treatment for myopic choroidal neovascularisation
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1Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China;
2Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi 445000, Hubei Province, China

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Supported by Hubei Province's Outstanding Medical Academic Leader Program and the Open Project of the State Key Laboratory of Ophthalmology (2013KF04)..
Conflicts of Interest:Zhou L, None; Xing YQ, None; Li T, None; Li Y, None; Song XS, None; Li JZ, None.

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    Abstract:

    AIM: To compare the best corrected visual acuity (BCVA) between Verteporfin with photodynamic therapy (PDT) and intravitreal anti-vascular endothelial growth factor (anti-VEGF) in patients with myopic choroidal neovascularization (CNV).METHOD: Published literature from Medline, Premedline, Embase and the Cochrane Library from inception until November 2013 were retrieved. All studies evaluating the BCVA between Verteporfin with PDT and intravitreal anti-VEGF for myopic CNV were included. The results were pooled using mean difference (MD), a corresponding 95% confidence interval (CI). RESULTS:Finally, five studies enrolled 349 eyes were included in the meta-analysis. We inferred that the BCVA of myopic CNV after the treatment of anti-VEGF was significantly better compared with Verteporfin with PDT (MD=0.25, 95%CI:0.17-0.33, Z=5.97, P<0.00001). CONCLUSION: This meta-analysis suggests that intravitreal anti-VEGF could have a better BCVA after treatment than Verteporfin with PDT for myopic CNV.

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Lin Zhou, Yi-Qiao Xing, Tuo Li, et al. Meta-analysis of best corrected visual acuity after treatment for myopic choroidal neovascularisation. Int J Ophthalmol, 2014,7(4):720-725

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Publication History
  • Received:July 30,2013
  • Revised:March 04,2014
  • Adopted:March 04,2014
  • Online: August 15,2014
  • Published: