Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy
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(1.Department of Ophthalmology, Zhuhai People’s Hospital, the Third Affiliated Hospital of Jinan University, Zhuhai 519000, Guangdong Province, China;2.Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China;3.Department of Ophthalmology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China;4.Department of Ophthalmology, the First Hospital of Nanchang, the Third Affiliated Hospital of Nanchang University, Nanchang 330038, Jiangxi Province, China)

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Supported byNatural Science Foundation of Ningxia (No.NZ10129).
Conflicts of Interest: Wu SL, None; Zhan DM, None; Xi SH, None; He XL, None.

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    Abstract:

    AIM:To investigate the role of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in proliferative diabetic retinopathy (PDR) and to discuss the correlations among t-PA, PAI and vascular endothelial growth factor (VEGF) expressions.METHODS: A total of 36 vitreous samples were collected from 36 patients with PDR (PDR group), and 17 vitreous samples from 17 patients with idiopathic macular hole were used as control. The concentrations of t-PA, PAI and VEGF in samples were determined by ELISA method. The correlations among t-PA, PAI and VEGF expressions were discussed.RESULTS: The concentrations of t-PA, PAI and VEGF in the PDR group were significantly higher than those in the control group (P<0.001). The t-PA and PAI expressions were highly correlated with the VEGF expression (P<0.001).CONCLUSION:In addition to VEGF, a variety of bioactive substances, such as t-PA and PAI, are involved in the pathogenesis involved in the angiogenesis of PDR. VEGF can activate t-PA expression, resulting in collagen tissue degradation and angiogenesis. VEGF may also activate the mechanism for endogenous anti-neovascularization.

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Shu-Ling Wu, Dong-Mei Zhan, Shu-Hong Xi, et al. Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy. Int J Ophthalmol, 2014,7(5):764-767

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Publication History
  • Received:December 18,2013
  • Revised:May 26,2014
  • Adopted:May 26,2014
  • Online: October 20,2014
  • Published: