Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty
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(1.Department of Optometry & Vision Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia;2.Senior Ophthalmology Consultant, Elite Medical & Surgical Center, Ulaya, P.O Box 65197, Riyadh 11556, Saudi Arabia;3.School of Optometry & Vision Science and Institute of Health & Biomedical Innovation, Chronic Disease and Aging Domain, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove 5SW36 QLD 4059, Australia)

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Conflicts of Interest: Arslan OS, None; Arici C, None; Unal M, None; Cicik E, None; Mangan MS, None; Atalay E, None

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    Abstract:

    AIM:To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP).METHODS:In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). The main outcome measures were anterior chamber reaction, best corrected visual acuity (BCVA), corneal endothelial cell count (ECC), and central corneal thickness (CCT).RESULTS:Fifty-five patients were recruited (26 males, 29 females). The mean age was 54.36±4.97y (range 45-64y). All eyes had improved postoperative BCVA. The mean BCVA was 0.25 preoperatively and 0.57 postoperatively, which was statistically significant (P<0.001). One eye had 3+, 7 eyes had 2+, 12 eyes had 1+ and 8 eyes had trace amount of aqueous cells on the first day after surgery. All eyes had no anterior chamber cells at subsequent follow up examinations. Effective phacoemulsification time was 4.33±1.01s. The mean ECC was 2340.20 cells/mm2 preoperatively and 1948.75 cells/mm2 1mo postoperatively (P<0.001). The increase of 21.09 μm in postoperative pachymetry 1mo after surgery was statistically significant (P<0.001).CONCLUSION: No untoward effects were observed after intracameral injection of moxifloxacin (0.5 mg/0.1 mL) in terms of anterior chamber reaction, CCT, ECC, and visual rehabilitation at the conclusion of cataract surgery in patients with PKP.

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Osman Sevki Arslan, Ceyhun Arici, Mustafa Unal, et al. Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty. Int J Ophthalmol, 2014,7(5):795-799

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Publication History
  • Received:September 07,2013
  • Revised:November 25,2013
  • Adopted:November 25,2013
  • Online: October 20,2014
  • Published: