Umbilical cord blood serum therapy for the management of persistent corneal epithelial defects
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(1.Ulucanlar Eye Training and Research Hospital, Ankara 06240, Turkey;2.Department of Ophthalmology, AtaturkTraining and Research Hospital, Ankara 06800, Turkey;3.Department of Radiology, Kecioren Training and Research Hospital, Ankara 06280, Turkey;4.Department of Ophthalmology, Kayseri Training and Research Hospital,Kayseri 38010, Turkey;5.Department of Ophthalmology, Bolu Izzet Baysal State Hospital, Bolu 14030, Turkey;6.Department of Ophthalmology, Yildirim Beyazit University School of Medicine, Ankara 06800, Turkey)

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Conflicts of Interest: Erdem E, None; Yagmur M, None; Harbiyeli I, None; Taylan-Sekeroglu H, None; Ersoz R, None.

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    Abstract:

    AIM:To evaluate the role of umbilical cord blood serum (CBS) therapy in cases with persistent corneal epithelial defects (PED).METHODS:Sixteen eyes of 14 patients with PED who were resistant to conventional treatment were treated with 20% umbilical cord serum eye drops. Patients were followed-up weekly until epithelization was complete. The collected data included the grade of corneal lesion (Grade I:epithelial defect+superficial vascularization, Grade II:epithelial defect+stromal edema, Grade III:corneal ulcer+stromal melting), the size of epithelial defect (pretreatment, 7th, 14th and 21st days of treatment), and follow-up time was evaluated retrospectively.RESULTS:The mean size of epithelial defect on two perpendicular axes was 5.2×4.6-mm2 (range:2.5-8×2.2-9 mm2). Mean duration of treatment was 8.3±5wk. CBS therapy was effective in 12 eyes (75%) and ineffective in 4 eyes (25%). The epithelial defects in 4 ineffective eyes were healed with amniotic membrane transplantation and tarsorrhaphy. The rate of complete healing was 12.5% by 7d, 25% by 14d, and 75% by 21d. The healing time was prolonged in Grade III eyes in comparison to eyes in Grade I or Grade II.CONCLUSION:The results of the current study indicated the safety effectiveness of CBS drops in the management of PED. The grade of disease seems have a role on the healing time.

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Elif Erdem, Meltem Yagmur, Inan Harbiyeli, et al. Umbilical cord blood serum therapy for the management of persistent corneal epithelial defects. Int J Ophthalmol, 2014,7(5):807-810

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Publication History
  • Received:November 16,2013
  • Revised:January 09,2014
  • Adopted:January 09,2014
  • Online: October 20,2014
  • Published: