Clinical study of customized aspherical intraocular lens implants
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(1.Department of Ophthalmology and Vision Sciences, Kayseri Traning and Research Hospital, Kocasinan-Kayseri 38010, Turkey;2.Department of Biostatistics, Faculty of Medicine, Erciyes University, Kocasinan-Kayseri 38010, Turkey)

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Conflicts of Interest: Jia LX, None; Li ZH, None.
ACKNOWLEDGEMENTS: The authors wish to thank Dr. T. Fitz Gibbon for comments and suggestions on earlier drafts of the manuscript. Gratitude is also extended to all of the patients for participating in the study.

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    Abstract:

    AIM:To compare if there is an improvement in visual functions with age-related cataracts between patients receiving a aspherical intraocular lens (IOL) based on corneal wavefront aberration and patients randomly assigned lenses.METHODS:A total of 124 eyes of 124 patients with age-related cataracts were placed in experimental group and a group receiving randomly assigned (RA) lenses. The experimental group was undergone Pentacam corneal spherical aberration measurement before surgery; the targeted range for residual total spherical aberration after surgery was set to 0-0.3 μm. Patients with a corneal spherical aberration <0.3 μm were implanted with a zero-spherical aberration advanced optics (AO) aspherical IOL and patients with an aberration ≥0.3 μm received a Tecnis Z9003 aspherical lens in experimental group. RA patients were randomly implanted with an AO lens or a Tecnis Z9003 lens. Three months after surgery total spherical aberration, photopic/mesopic contrast sensitivities, photopic/mesopic with glare contrast sensitivities, and logMAR vision were measured.RESULTS:Statistical analysis on logMAR vision showed no significant difference between two groups (P=0.413). The post-surgical total spherical aberration was 0.126±0.097 μm and 0.152±0.151 μm in the experimental and RA groups, respectively (P=0.12). The mesopic contrast sensitivities at spatial frequencies of 6, 12 and 18 c/d in the experimental group were significantly higher than of the RA group (P=0.00; P=0.04; P=0.02). The mesopic with glare contrast sensitivity in the experimental group at a spatial frequency of 18 c/d was also significantly higher vs the RA group (P=0.01).CONCLUSION:Pre-surgical corneal spherical aberration measurement in cataract patients followed by customized selection of aspherical IOL implants improved mesopic contrast sensitivities at high spatial frequencies, and thus is a superior strategy compared to the random selection of aspherical IOL implants.

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Lie-Xi Jia, Zhao-Hui Li. Clinical study of customized aspherical intraocular lens implants. Int J Ophthalmol, 2014,7(5):816-821

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Publication History
  • Received:March 20,2014
  • Revised:July 14,2014
  • Adopted:July 14,2014
  • Online: October 20,2014
  • Published: