Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma
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(1.Department of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, China;2.Department of Interventional Radiology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province, China)

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Conflicts of Interest: Ataş M, None; Demircan S, None; Karatepe Haşhaş AS, None; Gülhan A, None; Zararsız G, None.

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    Abstract:

    AIM:To evaluate intraocular pressure (IOP)-lowering effect and ocular tolerability of brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies in the management of primary open angle glaucoma.METHODS:Each drug was administered for two months, after which a circadian tonometric curve was recorded using a Goldmann applanation tonometer. Ocular discomfort (conjunctival hyperemia, burning or stinging, foreign body sensation, itching, ocular pain) of each eye was assessed by the subject on a standardized ocular discomfort scale.RESULTS:Among the three study groups, there were no significant differences in the mean baseline IOP measurements, mean 2nd mo IOP measurements, and mean (%) change of IOPs from baseline. Among the three study groups, there were no significant differences in the mean IOP measurements obtained at circadian tonometric curves at baseline and at two months controls. In sum brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar effects on IOP levels.CONCLUSION:Brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar lowering efficaties on IOP levels whereas there was no any difference between each other.

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Murat Atabey Ozer, Mutlu Acar, Cem Yildirim. Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma. Int J Ophthalmol, 2014,7(5):832-836

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Publication History
  • Received:January 04,2014
  • Revised:March 19,2014
  • Adopted:March 19,2014
  • Online: October 20,2014
  • Published: