Nanomedicine in the application of uveal melanoma
Author:
Corresponding Author:

Qing Zhang. Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China. annydaughter@gmail.com

Affiliation:

Clc Number:

Fund Project:

Supported by the National Natural Science Foundation of China (No. 81201808, No. 81502544); the American Fight For Sight Postdoctoral Award; Central South University Lieying grant; Emory University Melanoma Prevention and Research Discovery Fund; an unrestricted grant from Research to Prevent Blindness, Inc.

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Rapid advances in nanomedicine have significantly changed many aspects of nanoparticle application to the eye including areas of diagnosis, imaging and more importantly drug delivery. The nanoparticle-based drug delivery systems has provided a solution to various drug solubility-related problems in ophthalmology treatment. Nanostructured compounds could be used to achieve local ocular delivery with minimal unwanted systematic side effects produced by taking advantage of the phagocyte system. In addition, the in vivo control release by nanomaterials encapsulated drugs provides prolong exposure of the compound in the body. Furthermore, certain nanoparticles can overcome important body barriers including the blood-retinal barrier as well as the corneal-retinal barrier of the eye for effective delivery of the drug. In summary, the nanotechnology based drug delivery system may serve as an important tool for uveal melanoma treatment.

    Reference
    Related
    Cited by
Get Citation

Shuo You, Jing Luo, Hans E. Grossniklaus, et al. Nanomedicine in the application of uveal melanoma. Int J Ophthalmol, 2016,9(8):1215-1225

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:October 28,2015
  • Revised:February 16,2016
  • Adopted:
  • Online: August 15,2016
  • Published: