MMP-2 Rs24386 (C-->T) gene polymorphism and the phenotype of age-related macular degeneration
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Sandrita Simonyte. Intitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas LT-50161, Lithuania. sandrita.simonyte@lsmuni.lt

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Supported by Lithuanian Science Council (No.MIP-10330).

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    Abstract:

    AIM: To examine the MMP-2 (-1306 C/T) gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration (AMD) and geographic atrophy of late AMD form. METHODS: The study enrolled 850 investigations (290 AMD patients with soft and hard drusen, 34 with geographic atrophy and a random sample of the population n=526). Early AMD was classified according to the International Classification and Grading System. For geographic atrophy diagnosis the Age-Related Eye Disease Study classification was used. The potential association with single nucleotide polymorphisms on MMP-2 Rs243865 was evaluated for all patients, adjusted for age and sex. The genotyping test of MMP-2 Rs243865 (C-->T) was conducted using the real-time polymerase chain reaction method. RESULTS: MMP-2 (-1306 C/T) C/C genotype was more frequently detected in AMD patients with hard drusen than the soft drusen or control group (66.43% vs 53.74%, vs 54.94%, P=0.047). Logistic regression analysis showed that the MMP-2 (-1306) C/C genotype increased the likelihood to develop hard drusen in AMD patients (OR=1.7, 95% CI: 1.06-2.74; P=0.028). No association between MMP-2 (-1306 C/T) gene polymorphism in patients with atrophic AMD and control group was found (54.94%, 37.64%, 7.41% vs 50%, 38.24%, 11.76%; P=0.6). CONCLUSION: The MMP-2 Rs24386 (C-->T) polymorphism is found to be associated with the development of hard drusen in patients with AMD.

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Rasa Liutkeviciene, Vaiva Lesauskaite, Giedre Sinkunaite-Marsalkiene, et al. MMP-2 Rs24386 (C-->T) gene polymorphism and the phenotype of age-related macular degeneration. Int J Ophthalmol, 2017,10(9):1349-1353

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Publication History
  • Received:March 24,2016
  • Revised:June 23,2017
  • Adopted:
  • Online: September 05,2017
  • Published: