Intraocular pressure control of a novel glaucoma drainage device - in vitro and in vivo studies
Author:
Corresponding Author:

Li-Jun Cui. Department of Ophthalmology, the First Affiliated Hospital of Xi’an Jiaotong University. No.277, West Yanta Street, Xi’an 710061, Shaanxi Province, China. cuilijun@mail.xjtu.edu.cn

Affiliation:

Clc Number:

Fund Project:

Supported by National Natural Science Foundation of China (No.81300765).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To evaluate the intraocular pressure (IOP) control of an artificial trabeculum drainage system (ATDS), a newly designed glaucoma drainage device, and postoperative complications in normal rabbit eyes. METHODS: Pressure drops in air and fluid of 30 ATDS were measured after being connected to a closed manometric system. Twenty of them were then chosen and implanted randomly into the eyes of 20 rabbits. Postoperative slit-lamp, gonioscopic examination and IOP measurements were recorded periodically. Ultrasound biomicroscopy and B-scan ultrasonography were also used to observe the complications. Eyes were enucleated on day 60. RESULTS: Pressure drops of 4.6-9.4 mm Hg were obtained at physiological aqueous flow rates in the tests in vitro. The average postoperative IOP of the experimental eyes (11.6-12.8 mm Hg) was lower than the controls significantly (P<0.05) at each time point. Complications of hemorrhage (n=1), cellulosic exudation (two cases) and local iris congestion (two cases) were observed. The lumina of the devices were devoid of obstructions in all specimens examined and a thin fibrous capsule was found around the endplate. CONCLUSION: ATDS reduce IOP effectively. However, further studies on the structure are needed to reduce complications.

    Reference
    Related
    Cited by
Get Citation

Li-Jun Cui, Di-Chen Li, Jian Liu, et al. Intraocular pressure control of a novel glaucoma drainage device - in vitro and in vivo studies. Int J Ophthalmol, 2017,10(9):1354-1360

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:April 12,2017
  • Revised:June 26,2017
  • Adopted:
  • Online: September 05,2017
  • Published: