The association of lumican polymorphisms and high myopia in a Southern Chinese population
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Jing-Xiang Zhong. Department of Ophthalmology, the First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou 510630, Guangdong Province, China. lafangme@126.com

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Supported by Natural Science Foundation of Guangdong Province, China (No.2015A030310158; No.2014A030313359); the Science and Technology Planning Project of Guangdong Province, China (No.2015B020226003); the Scientific and Cultivation Foundation of the First Affiliated Hospital of Jinan University (No.2015201).

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    Abstract:

    AIM: To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population. METHODS: The study comprised of 95 high myopia patients with a spherical equivalent ≤?6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from ?0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg disequilibrium. Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher’s exact test. RESULTS: We identified 3 SNPs of the LUM gene: LUM c.32 (rs577456426), LUM c.507 (rs17853500) and LUM c.849 (rs181915277). Among the three SNPs, the genotype and allele frequencies of rs17853500 showed a significant difference between patients and control subjects (P<0.05). However, there were no significant differences in rs181915277 and rs577456426 between the two groups (P>0.05). CONCLUSION: LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population.

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Gui-Fang Wang, Qing-Shan Ji, Bing Qi, et al. The association of lumican polymorphisms and high myopia in a Southern Chinese population. Int J Ophthalmol, 2017,10(10):1516-1520

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Publication History
  • Received:November 17,2016
  • Revised:February 06,2017
  • Adopted:
  • Online: September 30,2017
  • Published: