The progress of prophylactic treatment in retinopathy of prematurity
Author:
Corresponding Author:

Hong-Bing Zhang. Department of Ophthalmology, Eye Institute of Shaanxi Province; Xi’an First Hospital, 30# Fenxiang, Nanda Avenue, Xi’an 710002, Shaanxi Province, China. zhanghongbing01@163.com; Xiao-Gang Li. Department of Internal Medicine; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. xli3@kumc.edu

Affiliation:

Clc Number:

Fund Project:

Supported by the National Natural Science Foundation of China (No.81570873); the Science and Technology Department of Shaanxi Province (No.2015JM8481).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Retinopathy of prematurity (ROP) is a retinal vascular disorder frequently found in premature infants. Different therapeutic strategies have been developed to treat ROP. However, there are still many children with ROP suffering by severe limitations in vision or even blindness. Recently, ROP has been suggested to be caused by abnormal development of the retinal vasculature, but not simply resulted by retinal neovascularization which takes about 4 to 6wk after birth in premature infants. Thus, instead of focusing on how to reduce retinal neovascularization, understanding the pathological changes and mechanisms that occur prior to retinal neovascularization is meaningful, which may lead to identify novel target(s) for the development of novel strategy to promote the healthy growth of retinal blood vessels rather than passively waiting for the appearance of retinal neovascularization and removing it by force. In this review, we discussed recent studies about, 1) the pathogenesis prior to retinal neovascularization in oxygen-induced retinopathy (OIR; a ROP in animal model) and in premature infants with ROP; 2) the preclinical and clinical research on preventive treatment of early OIR and ROP. We will not only highlight the importance of the mechanisms and signalling pathways in regulating early stage of ROP but also will provide guidance for actively exploring novel mechanisms and discovering novel treatments for early phase OIR and ROP prior to retinal neovascularization in the future.

    Reference
    Related
    Cited by
Get Citation

Hong-Bing Zhang, Xiao-Dong Wang, Kun Xu, et al. The progress of prophylactic treatment in retinopathy of prematurity. Int J Ophthalmol, 2018,11(5):858-873

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:June 13,2017
  • Revised:September 28,2017
  • Adopted:
  • Online: May 11,2018
  • Published: