Sangshin Park
Center for International Health Research, Rhode Island Hospital, the Warren Alpert Medical School of Brown University, Providence 02912, RI, USA; Department of Pediatrics, the Warren Alpert Medical School of Brown University, Providence 02912, RI, USANam-Kyong Choi
Department of Health Convergence, Ewha Womans University, Seoul 03760, Republic of KoreaNam-Kyong Choi. Department of Health Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. nchoi@ewha.ac.kr
AIM: To address the association between serum total IgE levels and age-related cataract in adults. METHODS: The study participants consisted of 1052 adults aged 40y or older in the Korean National Health and Nutrition Examination Survey 2010. We performed multivariable logistic regression analyses using the quartile cut-points of total IgE levels. RESULTS: The odds ratios (ORs) for nuclear and any cataract with ≥267 kU/L of serum IgE levels were 1.75 [95% confidence intervals (CI), 1.04-2.96] and 2.00 (95%CI, 1.22-3.27), respectively, comparing to 35-87 kU/L. Interestingly, participants with ≤35 kU/L of IgE levels (OR, 1.67; 95%CI, 1.02-2.72) also had higher risk for any cataract than those with 35-87 kU/L. The risk for any cataract (OR, 1.48; 95%CI, 1.03-2.13) was higher in participants with high total IgE levels (>150 kU/L), comparing to normal participants. CONCLUSION: Our findings indicate a J-shaped relationship between serum IgE levels and age-related cataract.
Sangshin Park, Nam-Kyong Choi. ,/et al.The J-shape association of serum total IgE levels with age-related cataract. Int J Ophthalmol, 2018,11(6):1009-1012
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