The diluted atropine for inhibition of myopia progression in Korean children
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Sun Young Shin. Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. eyeshin@catholic.ac.kr

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Supported by the Catholic Medical Center Research Foundation made in the program year of 2018 (No.5-2018-B0001-00006).

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    Abstract:

    AIM: To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. METHODS: A total of 285 children, with refractive errors within the range of -6 diopters (D) between 5 and 14 years of age were included. After using 0.01%, or 0.025%, or 0.05% atropine, for about 1y, changes in refraction, axial lengths and frequency of adverse events were analyzed. Logistic regression analyses were performed to evaluate the risk factors associated with rapid myopia progression. RESULTS: The changes in the mean spherical equivalent values were -0.134 D/mo in the before atropine group, -0.070 D/mo in the 0.01% atropine group, -0.047 D/mo in the 0.025% atropine group, and -0.019 D/mo in the 0.05% atropine group, with significant differences between the groups (P<0.001). The axial elongation was 0.046 mm/mo, 0.037 mm/mo, 0.025 mm/mo, and 0.019 mm/mo respectively, with significant differences between the groups (P=0.003). The incidence of photophobia and near vision difficulty was not different among the three atropine groups (P=0.425 and P=0.356, respectively). Multivariate logistic regression analyses showed that only highly myopic parents were a significant predictive factor of rapid myopia progression in Korean children (odds ratio, 8.155; 95% confidence interval, 3.626-18.342; P<0.001). CONCLUSION: Treatment with 0.01%, 0.025% and 0.05% atropine solution inhibits myopia progression in Korean children in a dose-dependent manner. Children with highly myopic parents preferentially shows a rapid myopia progression rate.

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Ji-Sun Moon, Sun Young Shin. The diluted atropine for inhibition of myopia progression in Korean children. Int J Ophthalmol, 2018,11(10):1657-1662

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Publication History
  • Received:July 02,2018
  • Revised:August 21,2018
  • Adopted:
  • Online: September 04,2018
  • Published: