Association between endoplasmic reticulum stress and risk factors of diabetic retinopathy
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Guang-Ying Zheng. Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, No.1 East Jianshe Road, Zhengzhou 450052, Henan Province, China. zzzgy@zzu.edu.cn

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Supported by the National Natural Science Foundation of China (No.81670836).

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    Abstract:

    Diabetic retinopathy (DR) is one of the most common and challenging ocular complications of diabetes mellitus. As a chronic, progressive ocular disease that poses a serious threat to vision, DR has gradually become a leading cause of blindness worldwide. Emerging evidence points to an important role of endoplasmic reticulum (ER) stress in not only maintaining the steady-state equilibrium in the body, but also in intracellular synthesis, protein folding, and other essential functions. Recent studies have demonstrated clear associations between ER stress-related physiological functions and the pathogenesis of DR. When cells are stimulated by external stimuli, UPR pathway is activated firstly to protect it. However, long-term harmful factors can induce ER stress. which interferes with the physiological metabolism of retinal cells and participates in the occurrence of DR via the ATF6 pathway, PERK pathway and IRE1 pathway. At present, ER stress blocker is expected to become a new anti-DR therapy. Thus, understanding the relationship between ER stress and DR will help to develop new effective preventative treatments. In this review, we summarize the risk factors of DR pathogenesis induced by ER stress toward revealing potentially new therapeutic targets.

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De-Qian Kong, Li Li, Yue Liu, et al. Association between endoplasmic reticulum stress and risk factors of diabetic retinopathy. Int J Ophthalmol, 2018,11(10):1704-1710

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Publication History
  • Received:December 27,2017
  • Revised:July 12,2018
  • Adopted:
  • Online: September 04,2018
  • Published: