Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review
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Shi-Bo Tang. Aier School of Ophthalmology, Central South University, Changsha 410015, Hunan Province, China. tangshibo@vip.163.com

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Supported by “555 Talent Plan” Grant from the Changsha National High-Tech Industrial Development Zoom.

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    Abstract:

    Glaucoma is a common optic neuropathy that is characterized by the progressive degeneration of axons and the loss of retinal ganglion cells (RGCs). Glaucoma is one of the leading causes of irreversible blindness worldwide. Current glaucoma treatments only slow the progression of RGCs loss. Induced pluripotent stem cells (iPSCs) are capable of differentiating into all three germ layer cell lineages. iPSCs can be patient-specific, making iPSC-derived RGCs a promising candidate for cell replacement. In this review, we focus on discussing the detailed approaches used to differentiate iPSCs into RGCs.

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Shang-Li Ji, Shi-Bo Tang. Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review. Int J Ophthalmol, 2019,12(1):152-160

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Publication History
  • Received:August 18,2017
  • Revised:September 06,2018
  • Adopted:
  • Online: January 03,2019
  • Published: