The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy
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Corresponding Author:

Yan Lu. Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. luyan366@126.com

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Supported by National Natural Science Foundation of China (No.81200719); China Postdoctoral Science Foundation (No.2013M543579; No.2014T71013); Key Specialized Projects in Nanjing (No.SZDZK2016008).

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    Abstract:

    Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments.

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Zhen-Mao Wang, Zheng-Yan Wang, Yan Lu. The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy. Int J Ophthalmol, 2019,12(7):1209-1214

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Publication History
  • Received:January 03,2019
  • Revised:May 21,2019
  • Adopted:
  • Online: June 11,2019
  • Published: