Evaluating correlation between the ocular biometry and genetic variants of MYOC and ABCA1 with primary angle-closure glaucoma in a cohort from northern China
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Wen-Juan Zhuang and Shao-Ping Ha. Ningxia Eye Hospital, People’s Hospital of Ningxia Hui Autonomous Region, 936 Huang He East Road, Yinchuan 750011, Ningxia Hui Autonomous Region, China. zh_wenj@163.com; hashaoping@163.com

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Supported by the National Natural Science Foundation of China (No.81460093); the Ningxia Nature Science Funding from the Department of Science and Technology of Ningxia Hui Autonomous Region (No.NZ16194).

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    Abstract:

    AIM: To investigate whether the gene variants in MYOC and ABCA1 are associated with primary angle-closure glaucoma (PACG) and anterior chamber depth (ACD) and axial length (AL) in samples from northern China. METHODS: The present case-control association study consisted of 500 PACG patients and 720 unrelated controls. Each participant was genotyped for eleven single nucleotide polymorphisms (SNPs) in MYOC and ABCA1 genes (rs12076134, rs183532, rs235875 and rs235913 in MYOC, rs2422493, rs2487042, rs2472496, rs2472493, rs2487032, rs2472459 and rs2472519 near ABCA1) using an improved multiplex ligation detection reaction (iMLDR) technique. The genetic association analyses were performed by PLINK using a logistic regression model. The association between genotypes and ocular biometric parameters was performed by SPSS using generalized estimation equation. Bonferroni corrections were implemented and the statistical power was calculated by the Power and Sample Size Calculation. RESULTS: Two SNPs rs183532 and rs235875 as well as a haplotype TTC in MYOC were nominally associated with PACG despite the significance was lost after Bonferroni correction. No association was observed between ABCA1 and PACG, neither did the association between these variants and ACD as well as AL. CONCLUSION: The present study suggests MYOC and ABCA1 do not play a part in the pathogenesis of PACG as well as the regulation of ocular biometric parameters in a northern Chinese population. Further investigations with large sample size are needed to verify this consequence.

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Shao-Lin Wang, Shun-Yu Piao, Man-Yun Xu, et al. Evaluating correlation between the ocular biometry and genetic variants of MYOC and ABCA1 with primary angle-closure glaucoma in a cohort from northern China. Int J Ophthalmol, 2019,12(8):1317-1322

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Publication History
  • Received:December 11,2018
  • Revised:June 03,2019
  • Adopted:
  • Online: July 09,2019
  • Published: