Atropine 0.01% eye drops slow myopia progression: a systematic review and Meta-analysis
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Xue-Jing Lu. Chengdu University of Traditional Chinese Medicine, 37 Twelve-Bridge Road, Chengdu 610075, Sichuan Province, China. xgl214@126.com

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Supported by National Major Science and Technology Project “Application of Multi-wavelength Structure Functional Retina Imager in Theoretical Research of Traditional Chinese Medicine” (No.2013YQ49085904); Sichuan Science and Technology Department-Research on the basic protection of retinal ganglion cells in traditional Chinese medicine (No.17CXTD0064); Chengdu Science and Technology Bureau-Promotion and demonstration of fundus screening technology for diabetic microangiopathy (No.2015-HM02-00093-SF).

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    Abstract:

    AIM: To evaluate the effects of atropine 0.01% on slowing myopia progression. METHODS: We searched for relevant studies in the Cochrane Library, PubMed, Embase, Ovid, CBM, CNKI, VIP and Wan Fang Data in Chinese. A supplementary search was conducted in OpenGrey (System for Information on Grey Literature in Europe), the ISRCTN registry, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform (ICTRP) from the dates of inception to June 30, 2018. RESULTS: Seven randomized controlled trials (RCTs) with a total of 1079 subjects were included (505 in the atropine 0.01% group and 574 in the control group). The results showed that the atropine 0.01% group exhibited significantly greater control of axial growth than the control group [MD=-0.12, 95%CI (-0.19, -0.06)]. There was also a statistically significant difference between the atropine 0.01% and control groups in the changes in axial length [MD=-0.14, 95%CI (-0.25, -0.03)], but the quality of evidence was low. There were no significant differences between the atropine 0.01% and control groups in the overall effect with respect to diopter value, change in diopter, distance vision and intraocular pressure [MD=0.08, 95%CI (-0.27, 0.42); MD=0.09, 95%CI (-0.17, 0.36); MD= -0.01, 95%CI (-0.02, 0.00); MD=0.08, 95%CI (-0.56,0.40)]. The sensitivity analysis showed that the conclusion of the Meta-analysis is relatively stable. With respect to adverse events, there were significant differences between the atropine 0.01% and control groups [OR=0.26, 95%CI (0.11, 0.61)]. CONCLUSION: Based on the available evidence, atropine 0.01% eye drops offer benefits in controlling axial growth and safety without causing significant differences in diopter values, distance vision and intraocular pressure.

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Ying Zhao, Kai Feng, Rui-Bao Liu, et al. Atropine 0.01% eye drops slow myopia progression: a systematic review and Meta-analysis. Int J Ophthalmol, 2019,12(8):1337-1343

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Publication History
  • Received:September 03,2018
  • Revised:June 04,2019
  • Adopted:
  • Online: July 09,2019
  • Published: