Relationship between intraocular pressure and parameters of obesity in ocular hypertension
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Jong Soo Lee. Department of Ophthalmology, Pusan National University College of Medicine, Medical Research Institute of Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan 49241, Korea. jongsod@pusan.ac.kr

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    Abstract:

    AIM: To evaluate the correlation between intraocular pressure (IOP) and various obesity-related health factors in patients with ocular hypertension in Korea. METHODS: A total of 40 850 subjects underwent age, sex, body weight, and height assessments and automated multiphasic tests, including non-contact tonometry, automated perimetry, fundus photography, systolic/diastolic blood pressure measurement, and evaluation of obesity-related health parameters such as obesity index, body mass index (BMI), a body shape index (ABSI), and waist-to-height ratio (WtHR). Subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and sex. RESULTS: Of 40 850 participants, 1515 (3.7%) had ocular hypertension, and 1515 with normal IOP were selected as controls using propensity score matching. The mean IOP of control group was 15.3±2.3 mm Hg, compared with 23.3±1.6 mm Hg in ocular hypertension group. Height, obesity index, BMI, and WtHR in the ocular hypertension group were significantly higher than in the normal IOP group (P<0.001, P<0.001, P=0.009, P=0.002). IOP of ocular hypertension was positively correlated with obesity index (P=0.027) and BMI (P=0.016), whereas IOP of control was positively correlated with blood pressure (P<0.001, P=0.002), obesity index (P<0.001), BMI (P<0.001), and WHtR (P=0.002). Systolic blood pressure (β=0.022, P<0.001) and body weight (β=0.016, P=0.02) were precursors of IOP in normal subjects, but sex (male; β=-0.231, P=0.008) and obesity index (β=-0.007, P=0.017) were precursors of ocular hypertension according to multiple regression analysis . CONCLUSION: Among various obesity-related health parameters, obesity index is the best indicator for further increase in IOP in ocular hypertension group.

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Min Won Ahn, Ji Woong Lee, Jong Hoon Shin, et al. Relationship between intraocular pressure and parameters of obesity in ocular hypertension. Int J Ophthalmol, 2020,13(5):794-800

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Publication History
  • Received:June 17,2019
  • Revised:February 19,2020
  • Adopted:
  • Online: March 30,2020
  • Published: