Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis
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Jiwon Baek. Department of Ophthalmology, Bucheon St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, #327 Sosa-ro, Wonmi-gu, Bucheon, Gyeonggi-do 14647, Republic of Korea. md.jiwon@gmail.com

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    Abstract:

    AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis. METHODS: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured in both affected and the fellow eyes at baseline, 1wk, 1 and 3mo. Changes in CT and CVI were analyzed in both eyes and compared between eyes. RESULTS: The mean CT and CVI were 349 μm and 0.70 in the affected eyes and 340 μm and 0.69 in the fellow eyes at baseline (P=0.503 and 0.440, respectively). Decrement of CT and CVI at month 3 were significant in affected eyes (P=0.017 and P<0.001). Decreased CVI began 2wk after treatment whereas CT decreased from 1mo. The CVI also decreased significantly in fellow eyes at 3mo compared to the baseline (P=0.001). CONCLUSION: A significant decrement in CT and CVI can appear after 3mo in optic neuritis patients treated with high-dose systemic corticosteroid treatment. The decrease in CVI appeared earlier than the decrease in CT, suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.

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Jun Hyuk Lee, Ji Young Lee, Ho Ra, et al. Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis. Int J Ophthalmol, 2020,13(9):1430-1435

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Publication History
  • Received:September 25,2019
  • Revised:March 19,2020
  • Adopted:
  • Online: July 21,2020
  • Published: