Citation:Yang YL,Jian Q,Liu B,Wang K,Chen YJ,Tan L,Pu MJ,Liu Y.Fourier-domain optical coherence tomography-guided phototherapeutic keratectomy for the treatment of anterior corneal scarring.Int J Ophthalmol 2020;13(11):1720-1726,doi:10.18240/ijo.2020.11.06
Fourier-domain optical coherence tomography-guided phototherapeutic keratectomy for the treatment of anterior corneal scarring
Received:August 05, 2019  Revised:October 25, 2019
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DOI:10.18240/ijo.2020.11.06
Key Words:corneal scar  phototherapeutic keratectomy  fourier-domain optical coherence tomography  corneal opacity  corneal topographic indices
Fund Project:Supported by Grants from National Natural Science Foundation of China (No.81900830); National Key Research & Development Intensification Key Project (No.2016YFC1101103; No.2018YFA0107302); Basic Science and Frontier Technology Project in Chongqing Science and Technology Commission (No.cstc2016jcyjA0297).
                       
AuthorInstitution
Yu-Li Yang Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Qian Jian Chongqing Aier Mega Eye Hospital, Aier Eye Hospital Group, Chongqing , China
Bo Liu Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Ke Wang Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Yu-Juan Chen Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Lian Tan Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Mei-Jun Pu Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
Yong Liu Southwest Hospital/Southwest Eye Hospital, Third Military Medical University Army Medical University, Chongqing , China
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Abstract:
      AIM: To evaluate the safety, visual and anatomic outcomes of fourier-domain optical coherence tomography (FD-OCT)-guided excimer laser phototherapeutic keratectomy (PTK) combined with photorefractive keratectomy (PRK) surgery in treating anterior corneal scarring.

    METHODS: Clinical data of 23 eyes of 21 patients with anterior corneal scarring underwent FD-OCT-guided PTK and PRK from Dec. 2014 to Jul. 2016 were reviewed. Patients were assessed for preoperative and postoperative uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), contrast sensitivity (CS), FD-OCT, corneal topography and colour figures of anterior segments.

    RESULTS: The preoperative corneal pathologic conditions included viral keratitis (7 patients, 7 eyes), band keratopathy (2 patients, 4 eyes), corneal dystrophy (4 patients, 4 eyes), traumatic corneal disease (2 patients, 2 eyes) and corneal chemical injury (6 patients, 6 eyes). Mean follow-up time was 10.65 (range, 3-19)mo. UCVA (in logMAR) improved from a mean of 0.79 (95%CI, 0.28-1.29) preoperatively to a mean of 0.45 (95%CI, 0.29-0.62) postoperatively (P=0.021). BSCVA (in logMAR) improved from 0.57 (95%CI, 0.27-0.88) preoperatively to a mean of 0.28 (95%CI, 0.15-0.41) postoperatively (P=0.001). Corneal topographic indices postoperatively showed significant improvement in corneal cylinder (P=0.009), the surface regularity index (P=0.007) and surface asymmetry index (P=0.00). Postoperative spherical equivalent averaged -0.53 diopters (-1.49 to 0.42). No complications were associated with the treatment.

    CONCLUSION: FD-OCT-guided PTK combined with PRK is safe and effective for the treatment of anterior corneal scarring by eliminating or reducing corneal opacities.

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