Citation:Ni YQ,Xu SS,Zhang T,Huang X.Clinical features and changes of disease spectrum of zone II retinopathy of prematurity: a 10-year review.Int J Ophthalmol 2020;13(11):1753-1757,doi:10.18240/ijo.2020.11.11
Clinical features and changes of disease spectrum of zone II retinopathy of prematurity: a 10-year review
Received:January 12, 2020  Revised:April 27, 2020
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DOI:10.18240/ijo.2020.11.11
Key Words:retinopathy of prematurity  classification  natural evolution  zone
Fund Project:Supported by research grants from National Natural Science Foundation (No.81570855).
           
AuthorInstitution
Ying-Qin Ni Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai , China
Si-Si Xu Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai , China
Ting Zhang Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai , China
Xin Huang Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai , China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai , China
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Abstract:
      AIM: To report the clinical features and evolution of zone II retinopathy of prematurity (ROP).

    METHODS: RetCam images of preterm infants with zone II ROP at our hospital between January 2009 and January 2019 were reviewed. The location, extent, and severity of ROP were recorded. Eyes were classified as type 1 zone II, type 2 zone II, and mild zone II ROP. The clinical features and evolution of zone II ROP were analyzed.

    RESULTS: In total, 184 infants (302 eyes) were enrolled. Of these, 55 eyes (18%) developed type 1 zone II ROP, 39 eyes (13%) developed type 2 zone II ROP, and 208 eyes (69%) developed mild zone II ROP. The proportion of type 1 zone II ROP significantly decreased over the 10y. The onset of type 2 zone II and mild zone II ROP were 1wk earlier than type 1 zone II, and both regressed at 45wk. Isolated neovascular tuft (popcorn) and double track signs were characteristic manifestations of zone II ROP. Eighty-seven percent of type 1 zone II ROP regressed completely with an unfavorable outcome that emerged in seven eyes after laser treatment.

    CONCLUSION: Zone II is an area with ROP disease at various risk levels. Zone II ROP has unique clinical presentations like popcorn and double track signs. Over time, the proportion of zone II ROP with high risk gradually decrease and respond well to therapy.

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