Citation:Zhu XY,Li J,Guan WB,Chen CL,Ji XD,Zhao PQ.Pathologic comparisons of enucleated eyes with retinoblastoma after superselective ophthalmic arterial chemotherapy with or without intravenous chemotherapy.Int J Ophthalmol 2020;13(11):1794-1799,doi:10.18240/ijo.2020.11.17
Pathologic comparisons of enucleated eyes with retinoblastoma after superselective ophthalmic arterial chemotherapy with or without intravenous chemotherapy
Received:November 04, 2019  Revised:March 19, 2020
Email this Article  Add to Favorites  Print
DOI:10.18240/ijo.2020.11.17
Key Words:retinoblastoma  chemotherapy  pathology
Fund Project:Supported by the National Natural Science Foundation of China (No.81770964); Shanghai Science and Technology Committee (No.17411952900).
                 
AuthorInstitution
Xiu-Yu Zhu Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai , China
Jing Li Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai , China
Wen-Bin Guan Department of Pathology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai , China
Chun-Li Chen Department of Ophthalmology, Tianjin Medical University Eye Hospital & Tianjin Medical University Eye Institute, Tianjin , China
Xun-Da Ji Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai , China
Pei-Quan Zhao Department of Ophthalmology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai , China
Hits: 207
Download times: 40
Abstract:
      AIM: To describe and compare pathologic findings in eyes enucleated after superselective ophthalmic arterial chemotherapy (SOAC) or SOAC with intravenous chemotherapy (IVC) for retinoblastoma.

    METHODS: Medical records between January 1st, 2014 and June 30th, 2017 were retrospectively analyzed, and pathologic findings were recorded. This study included 36 eyes from 22 (61.1%) male and 14 (38.9%) female patients. Nineteen of 36 (52.8%) eyes received SOAC (mean=3, range=1-7) as primary treatment, and 17 of 36 (47.2%) eyes received SOAC (mean=3.7, range=1-10) after IVC (mean=6.1, range=2-11). Tumor extension including choroidal invasion (n=9, 25%), optic nerve invasion (n=5, 13.9%) and anterior segment invasion (n=5, 13.9%) were recorded.

    RESULTS: Histopathologic evidence of ischemic damage in the retina and choroid was found in 28 (77.8%) eyes. Thrombosed blood vessels were identified in 9 (25%) eyes, including orbital artery in the retrobulbar orbit (n=1), intrascleral vessels (n=4), and chorioretinal vessels (n=6). Fibrotic changes were found in extraocular muscles (n=5, 13.9%) and optic nerve (n=5, 13.9%). Varying degrees of scleral degeneration were found in all eyes. In statistical analysis, there was no significant difference in clinical and pathologic changes between SOAC group and SOAC with IVC group except for optic nerve invasion (P=0.047).

    CONCLUSION: SOAC for retinoblastoma can result in ocular toxicity, and SOAC with IVC do not increase the toxicity but reduce the incidence of optic nerve invasion.

PMC FullText Html:
Supplementary Material
PDF Fulltext  Download reader  HTML Fulltext   View/Add Comment