Citation:Sheng Y,Guo YZ,Xu LJ,Zhu B.Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients.Int J Ophthalmol 2020;13(11):1800-1807,doi:10.18240/ijo.2020.11.18
Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients
Received:April 15, 2020  Revised:July 10, 2020
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DOI:10.18240/ijo.2020.11.18
Key Words:cytomegalovirus retinitis  optical coherence tomography  fundus autofluorescence
Fund Project:Supported by the National Science and Technology Major Project of China during the 13th Five-year plan period (No.2018ZX10302104).
           
AuthorInstitution
Yan Sheng Department of Ophthalmology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang Province, China
Yong-Zheng Guo Department of Infectious Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang Province, China
Li-Jun Xu Department of Infectious Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang Province, China
Biao Zhu Department of Infectious Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang Province, China
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Abstract:
      AIM: To observe the findings of spectral domain optical coherence tomography (SD-OCT) scan in cytomegalovirus retinitis (CMVR).

    METHODS: Forty-six eyes of 33 patients with acquired immunodeficiency syndrome and CMVR were enrolled in the study. Complete ophthalmologic examinations, color fundus photography, SD-OCT and fundus autofluorescence (FAF) were performed for all patients at the first visit and each follow-up visit. Retinal necrosis in CMVR was analyzed on SD-OCT and classified into two types, the typical type and the atypical type.

    RESULTS: Forty-one eyes of active CMVR and 4 eyes of recurrent CMVR were classified into typical type, and 4 eyes with graying retinal lesion without hemorrhage or only punctate hemorrhage were classified into atypical type. In active stage of CMVR, the retina in typical type was significant thickened with hyperreflective lesion and full-thickness disruption of retinal architecture with enlarged vessel; while in atypical type, the retina was also destroyed in all layers but without thickening or slightly thinned. The choroid, vitreous and retinal vessels were not significantly involved. In healed stage, the retina was thin with destroyed layers in both types. In typical type, FAF showed mottled hypofluorescence mixed with punctuate hyperfluorescence. In atypical type, the retina showed some “cavity” in outer nuclear layer, and FAF showed mild hyperfluorescence.

    CONCLUSION: SD-OCT show different changes in the retina in typical type and atypical type of CMVR, which should be useful in assisting diagnosis and follow-up management of the disease.

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