Citation:Pluzsik MT,Tóth G,Tóth J,Matolcsy A,Langenbucher A,Kerényi A,Nagy ZZ,Szentmáry N.Changing trends in penetrating keratoplasty indications at a tertiary eye care center in Budapest, Hungary between 2006 and 2017.Int J Ophthalmol 2020;13(11):1814-1819,doi:10.18240/ijo.2020.11.20
Changing trends in penetrating keratoplasty indications at a tertiary eye care center in Budapest, Hungary between 2006 and 2017
Received:September 12, 2019  Revised:October 23, 2019
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DOI:10.18240/ijo.2020.11.20
Key Words:penetrating keratoplasty  indications  histology
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Milán Tamás Pluzsik Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary; Department of Ophthalmology, Bajcsy-Zsilinszky Hospital, Budapest 1106, Hungary
Gábor Tóth Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary
Jeannette Tóth nd Department of Pathology, Semmelweis University, Budapest 1091, Hungary
András Matolcsy st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest 1085, Hungary
Achim Langenbucher Experimental Ophthalmology, Saarland University, Homburg/Saar 66421, Germany
Agnes Kerényi Department of Ophthalmology, Bajcsy-Zsilinszky Hospital, Budapest 1106, Hungary
Zoltán Zsolt Nagy Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary
Nóra Szentmáry Department of Ophthalmology, Semmelweis University, Budapest 1085, Hungary; Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University Homburg/Saar 66424, Germany
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Abstract:
      AIM: To analyze the changing trends in penetrating keratoplasty (PKP) indications.

    METHODS: This retrospective study included all patients with PKP between 2006 and 2017. Patients were classified using histological diagnoses. Our groups were as the following: pseudophakic or aphakic bullous keratopathy, regraft, acute necrotizing and ulcerative keratitis, keratoconus, Fuchs’ dystrophy, corneal dystrophy other than Fuchs’, corneal scar, other diagnoses and failed endothelial keratoplasty graft. Additionally, two different time-periods (2006-2012 and 2013-2017) were analysed.

    RESULTS: Totally 1721 histological analyses of 1214 patients were available for review. The diagnoses were pseudophakic or aphakic bullous keratopathy in 487 (28.3%), regraft in 443 (25.7%), acute necrotizing and ulcerative keratitis in 313 (18.2%), corneal scar in 153 (8.9%), keratoconus in 140 (8.1%). Fuchs’ dystrophy in 61 (3.5%), corneal dystrophy other than Fuchs’ in 46 (2.7%), other diagnoses in 44 (2.6%) and failed endothelial keratoplasty graft in 34 (2.0%) cases. From the first to the second analysed time-period, incidence of acute necrotizing and ulcerative keratitis, corneal scar, Fuchs’ dystrophy increased (P≤0.032 for all) and incidence of keratoconus significantly decreased (P=0.015).

    CONCLUSION: Pseudophakic or aphakic bullous keratopathy is the leading indication for PKP, followed by regraft and acute necrotizing and ulcerative keratitis.

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