Citation:Lu K,Du HT,Lian AL,Su Y,Wang F.Effect of purine-rich box1 on proliferation of fibroblasts.Int J Ophthalmol 2020;13(11):1827-1832,doi:10.18240/ijo.2020.11.22
Effect of purine-rich box1 on proliferation of fibroblasts
Received:December 31, 2019  Revised:May 27, 2020
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DOI:10.18240/ijo.2020.11.22
Key Words:purine-rich box1  TGF-β  extracellular matrix  fibroblasts  fibrosis  ocular tissue
Fund Project:Supported by the National Natural Science Foundation of China (No.81470633); the Natural Science Grant of the Heilongjiang Province of China (No.H2018035; No.LH2020H040); the Innovation and Development Foundation of the First Affiliated Hospital of Harbin Medical University (No.2018L002).
              
AuthorInstitution
Ke Lu Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Hai-Tao Du Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Ai-Ling Lian Department of Centric Operating Room, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Ying Su Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Feng Wang Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
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Abstract:
      Fibroblasts are pleomorphic cells that have a multi-directional effect on organ morphogenesis, tissue homeostasis, and immune response. In fibrotic diseases, fibroblasts synthesize large amounts of extracellular matrix (ECM), leading to scarring and organ failure. Purine-rich box1 (PU.1) is a specific transcription factor of hematopoietic cell and belongs to the E26 transformation specificity (ETS) family. Recently, it was found that the transcription factor PU.1 is an important regulatory factor of the profibrotic gene expression program. TGF-β had been proved to play an important role in many ocular tissue fibrosis diseases, and up-regulated the expression of PU.1 in fibroblasts producing ECM in a Smad-3 dependent manner. We explore the effect of PU.1 on fibrosis of different ocular tissues from this perspective. This article reviews the role of PU.1 and its effects on fibrosis of ocular tissue and other tissues.
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