Dynamic versus static ultra-widefield fluorescein angiography in eyes with diabetic retinopathy: a pilot prospective cross-sectional study
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Ji-Li Chen. Department of Ophthalmology, Shanghai Shibei Hospital, No.4500 Gonghexin Road, Shanghai 200435, China. corneachen@163.com; Xun Xu. Department of Ophthalmology, Shanghai General Hospital, No.100 Haining Road, Shanghai 200080, China. drxuxun@sjtu.edu.cn

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Supported by National Natural Science Foundation of China (No.81570851); Project of Shanghai Medical Key Specialty Construction (No.ZK2019B27); National Project of Shanghai Municipal Commission of Health and Family Planning (No.201740001); Project of Shanghai Jingan District Municipal Commission of Health and Family Planning (No.2018MS12); Advanced and Appropriate Technology Promotion Project of Shanghai Health Commission (No.2019SY012); Shanghai Jiao Tong University Translation Medicine Cross Research Fund Project (No.YG2019QNA61).

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    Abstract:

    AIM: To analyze differences in ultra-widefield fluorescein angiography (UWFA) findings between dynamic and static images of eyes with diabetic retinopathy (DR). METHODS: This cross-sectional study included 28 eyes of 28 patients with DR undergoing UWFA. A series of UWFA images acquired from each patient were converted into a time-lapse video and used as a dynamic image. A single, clear, arteriovenous phase image was chosen as a static image. Non-perfusion index (NPI) and its correlation with vascular abnormalities in different zones were compared between dynamic and static UWFA imaging. RESULTS: NPI appeared to increase from the center to the far-periphery in both groups. Dynamic NPI was lower in the total retinal area (0.26 vs 0.29, P=0.009) and far-periphery (0.33 vs 0.36, adjusted P=0.042), which was contrary to the static NPI. Far-peripheral NPI was associated with intraretinal microvascular abnormality in the posterior area in both groups. CONCLUSION: Time-lapse dynamic UWFA imaging is a useful modality to differentially diagnose hypofluorescence in the most peripheral region. This modality could provide a reliable method for NPI measurement.

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Hang-Qi Shen, Jing Wang, Tian Niu, et al. Dynamic versus static ultra-widefield fluorescein angiography in eyes with diabetic retinopathy: a pilot prospective cross-sectional study. Int J Ophthalmol, 2021,14(3):409-415

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Publication History
  • Received:November 03,2020
  • Revised:November 25,2020
  • Adopted:
  • Online: February 24,2021
  • Published: