Applications of the isolated-check visual evoked potential in primary open angle glaucoma with or without high myopia
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Ying-Zi Pan. Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China. panyingzi99@126.com

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    Abstract:

    AIM: To explore the diagnostic performance of isolated-check visual evoked potential (icVEP) for primary open angle glaucoma (POAG) in both highly myopic and non-highly myopic populations and compare it with those of optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) parameters. METHODS: A total of 126 participants were recruited, including 31 highly myopic participants with POAG (HM-POAG), 36 non-highly myopic participants with POAG (NHM-POAG), 25 highly myopic participants without POAG (HM) and 34 controls without high myopia (Normal). All the participants underwent a complete ophthalmic examination. The signal-to-noise ratio (SNR) was used to assess the icVEP. Both qualitative and quantitative diagnostic performances of OCT, HRT and the icVEP were analyzed and compared. RESULTS: Based on the criterion of SNR≤1, the diagnostic performance of the icVEP in highly myopic subjects [area under the receiver operating characteristic curve (AUC)=0.862] was better than that in non-highly myopic subjects (AUC=0.789), and the SNR had fairly good specificity. In distinguishing the HM-POAG and HM groups, the AUC of the SNR was not different from those of the OCT and HRT parameters (P>0.05) in either the qualitative or quantitative comparison. In the qualitative analysis, the icVEP showed good consistency with damage to the central 10° of the visual field (kappa=0.695-0.747, P<0.001). CONCLUSION: The icVEP has the potential to discriminate individuals with and without POAG, especially in populations with high myopia.

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Xia Wang, Ruo-Shi Li, Ya-Hui Wei, et al. Applications of the isolated-check visual evoked potential in primary open angle glaucoma with or without high myopia. Int J Ophthalmol, 2021,14(5):704-713

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Publication History
  • Received:November 26,2020
  • Revised:January 20,2021
  • Adopted:
  • Online: March 29,2021
  • Published: