Citation:Jiang JW,Yi ZHZ,Wang XL,Liu JJ,Sun GP,Chen CZ.Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography.Int J Ophthalmol 2021;14(12):1915-1920,doi:10.18240/ijo.2021.12.16
Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
Received:March 21, 2021  Revised:August 26, 2021
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DOI:10.18240/ijo.2021.12.16
Key Words:ultra-widefield fluorescein angiography  retinal  vasculature  imaging
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Jing-Wen Jiang Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
Zuo-Hui-Zi Yi Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
Xiao-Ling Wang Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
Jue-Jun Liu Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
Gong-Peng Sun Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
Chang-Zheng Chen Eye Center, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China
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Abstract:
      AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA).

    METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to define the edge of retinal vasculature by a certified grader. The length from the center of the optic disc to the edge of retinal vascularity (RVL) in each quadrant and the total retinal vascular perfusion area (RVPA) were determined by the grader using OptosAdvance software. The density of retinal vascularity (RVD) was quantified in different zones of central-steered images using Image J software.

    RESULTS: Among 42 healthy eyes, the values for mean RVL in each quadrant were 19.007±0.781 mm (superior), 18.467±0.869 mm (inferior), 17.738±0.622 mm (nasal) and 24.241±1.336 mm (temporal). The mean RVPA was 1140.117±73.825 mm2. The mean RVD of the total retina was 4.850%±0.638%. RVD varied significantly between different retina zones (P<0.001), and significant differences existed in the RVD values for total retinal area in patients over 50 years old compared to those under 50 years old (P=0.033). No gender difference was found.

    CONCLUSION: The UWFA device can be a promising tool for analyzing the overall retinal vasculature and may provide a better understanding of retinal vascular morphology in normal eyes. Aging may be related to lower RVD.

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