Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs
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Tao Chen and Zuo-Ming Zhang. Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China. ct1988@fmmu.edu.cn and zhangzm@fmmu.edu.cn; Wei Wang. Naval Medical Center of PLA, Shanghai 200433, China. wwang_fd@fudan.edu.cn

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Supported by the Key Research Plan of Shaanxi Province, China (No.2018SF-257); the Key Project of Equipment Scientific Research (No.172B02027).

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    Abstract:

    AIM: To explore the effects of laser-activated remote phosphors (LARP) on visual function in guinea pigs. METHODS: Electroretinogram (ERG) of guinea pigs were observed after LARP irradiation at different frequencies and irradiation times. We evaluated the expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP irradiation. RESULTS: After LARP irradiation, the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation (P<0.05). The expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pig declined. CONCLUSION: There is frequency cumulative damage effect on the retina that relates to LARP illumination frequency. This has significance for staff visual protection policies under LARP lighting conditions.

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Yu-Fei Zhang, Xiao-Hong Zhou, Rui-Dan Cao, et al. Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs. Int J Ophthalmol, 2022,15(2):213-220

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Publication History
  • Received:March 05,2021
  • Revised:September 23,2021
  • Adopted:
  • Online: January 26,2022
  • Published: