Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis
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Sung Who Park. Department of Ophthalmology, School of Medicine, Pusan National University & Medical Research Institute, Pusan National University Hospital, Pusan 48060, Republic of Korea. oph97@naver.com

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    Abstract:

    AIM: To evaluate the safety of using 0.03% trypan blue under air for anterior capsule staining in cataract surgery. METHODS: The current study involved a retrospective analysis of the medical records of 86 patients with vitreous hemorrhage, who underwent pars plana vitrectomy and cataract surgery. The patients were classified into two groups. The trypan blue group (n=45) comprised patients who underwent anterior capsule staining with 0.03% trypan blue under an air bubble. The control group (n=41) comprised of patients who underwent intracameral illuminator-assisted capsulorhexis. The status of endothelial cell density (ECD) in both the groups was analyzed. RESULTS: The trypan blue group displayed significant decline in ECD at 1mo (7.91% loss, P<0.001) and 3mo (9.65% loss, P<0.001) after the surgery, whereas no significant changes were observed in the control group. Moreover, the number of patients who did not display a postoperative decline in ECD was significantly higher in the control group (43.9%; 18 patients) than in the trypan blue group (17.1%; 7 patients, P=0.004). CONCLUSION: Anterior capsule staining with trypan blue under the air bubble would not be as safe as the intracameral illuminator. The ECD loss might be attributed to the air bubble rather than to the deleterious effects of 0.03% trypan blue. Further studies are required to clarify this.

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Young Min Park, Jong Soo Lee, Ji Eun Lee, et al. Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis. Int J Ophthalmol, 2022,15(3):432-437

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Publication History
  • Received:October 26,2020
  • Revised:October 13,2021
  • Adopted:
  • Online: March 01,2022
  • Published: