Chao Pan
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China; Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaWei-Na Tan
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China; Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaDan Chen
Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaYu Liu
Aier School of Ophthalmology, Central South University, Changsha 410083, Hunan Province, ChinaHao-Yu Wang
Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaDeng-Feng Liang
Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaYan-Jun Hua
Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaXiao-Hua Lei
Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaQing-Yan Zeng
Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, ChinaShao-Zhen Zhao
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, ChinaQing-Yan Zeng. Hankou Aier Eye Hospital, Wuhan 430000, Hubei Province, China. zengqingyan1972@163.com; Shao-Zhen Zhao. Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin 300384, China. zhaosz1997@sina.com
Supported by the National Natural Science Foundation of China (No.81970769); Hunan Province Technology Innovation Guidance Program (No.2018SK50108); Wuhan City Medicine Research Project (No.WX19C12); Ophthalmology and Otorhinolaryngology College of Hubei University of Science and Technology Research Development Fund Project (No.2020XZ38).
AIM: To detect an earlier improvement in mild to moderate keratoconus following corneal cross-linking (CXL) with total corneal refractive power (TCRP) using ray tracing method. METHODS: A total of 40 eyes of 30 consecutive patients who underwent CXL for progressive keratoconus were retrospectively enrolled. The following keratometric parameters provided by Pentacam HR, including maximum keratometry (Kmax), steepest keratometry (Ksteep), 3 mm zonal TCRP centered over corneal apex (TCRPapex,zone 3 mm), zonal mean keratometry and TCRP centered over corneal cone (Kmcone,zone and TCRPcone,zone 1, 2, 3 mm) were evaluated preoperatively and 1, 3, 6, and 12mo postoperatively. Groups 1 and 2 were defined based on Kmax at postoperative 1mo as improved (the initial improvement group) or worsen (the initial deterioration group) compared to the preoperative level. RESULTS: In the overall group, only keratometric parameters based on ray tracing method displayed significant improvement early at 3mo postoperatively, in which TCRPcone,zone 1 mm and 2 mm exhibited the largest flattening (0.57 D and 0.53 D, respectively). In Group 1, only Kmax, Kmcone,zone 2 mm and TCRPcone,zone 2 mm showed significant improvement initially at 1mo postoperatively, in which Kmax exhibited the largest improvement (1.05 D), followed by TCRPcone,zone 2 mm (0.82 D). In Group 2, only keratometric parameters based on ray tracing method and Kmcone,zone 3 mm showed slight but not significant improvement early at 3mo, in which TCRPcone,zone 3 mm displayed the most improvement (0.19 D), followed by TCRPcone,zone 2 mm (0.15 D). CONCLUSION: The findings indicate that a 2 mm zonal TCRP centered over Kmax could earlier detect keratometric improvement by CXL compared to other commonly used parameters in mild to moderate keratoconic eyes.
Chao Pan, Wei-Na Tan, Dan Chen,/et al.A novel analysis of Scheimpflug total corneal refractive power following corneal cross-linking in mild to moderate keratoconus. Int J Ophthalmol, 2022,15(5):728-735
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