Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma
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Yu-Hua Tong. Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China. yuhuatong@126.com; Wei-Hua Yang. Shenzhen Eye Hospital, Shenzhen 518040, Guangdong Province, China. benben0606@139.com

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Supported by Zhejiang Province Public Welfare Technology Application Research Project (No.LGF22H120017); Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialists (No.SZGSP014); Sanming Project of Medicine in Shenzhen (No.SZSM202011015); Shenzhen Fundamental Research Program (No.JCYJ20220818103207015).

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    Abstract:

    AIM: To measure the retinal vessels of primary open angle glaucoma (POAG) patients on spectral domain optical coherence tomography (SD-OCT) with a full-width at half-maximum (FWHM) algorithm to better explore their structural changes in the pathogenesis of POAG. METHODS: In this retrospective case-control study, the right eyes of 32 patients with POAG and 30 healthy individuals were routinely selected. Images of the supratemporal and infratemporal retinal vessels in the B zones were obtained by SD-OCT, and the edges of the vessels were identified by the FWHM method. The internal and external diameters, wall thickness (WT), wall cross-sectional area (WCSA) and wall-to-lumen ratio (WLR) of the blood vessels were studied. RESULTS: Compared with the healthy control group, the POAG group showed a significantly reduced retinal arteriolar outer diameter (RAOD), retinal arteriolar lumen diameter (RALD) and WSCA in the supratemporal (124.22±12.42 vs 138.32±10.73 µm, 96.09±11.09 vs 108.53±9.89 µm, and 4762.02±913.51 vs 5785.75±1148.28 µm2, respectively, all P<0.05) and infratemporal regions (125.01±15.55 vs 141.57±10.77 µm, 96.27±13.29 vs 110.83±10.99 µm, and 4925.56±1302.88 vs 6087.78±1061.55 µm2, all P<0.05). The arteriolar WT and WLR were not significantly different between the POAG and control groups, nor were the retinal venular outer diameter (RVOD), retinal venular lumen diameter (RVLD) or venular WT in the supratemporal or infratemporal region. There was a positive correlation between the arteriolar parameters and visual function. CONCLUSION: In POAG, narrowing of the supratemporal and infratemporal arterioles and a significant reduction in the WSCA is observed, while the arteriolar WT and WLR do not change. Among the venular parameters, the external diameter, internal diameter, WT, WLR, and WSCA of the venules are not affected.

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Jia-Peng Wang, Mei-Ting Yu, Bo-Lun Xu, et al. Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma. Int J Ophthalmol, 2023,16(5):671-679

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Publication History
  • Received:March 01,2023
  • Revised:March 20,2023
  • Adopted:
  • Online: April 27,2023
  • Published: