Retinal thickness and fundus blood flow density changes in chest pain subjects with dyslipidemia
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Qing-Jian Li and Zhi-Liang Wang. Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai 200040, China. liqingjianvip@163.com; ophwzl@163.com

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Supported by the Science and Technology Commission of Shanghai Municipality (No.20Y11910800).

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    Abstract:

    AIM: To assess the retinal thickness and fundus blood flow density changes in chest pain patients with dyslipidemia using optical coherence tomography angiography (OCTA). METHODS: All subjects with chest pain as the main symptom accepted a comprehensive ophthalmological examination. According to the serum lipid levels, the participants were divided into the control group and the dyslipidemia group. The retina thickness and fundus blood flow density were determined using OCTA. RESULTS: The study enrolled 87 left eyes from 87 adults with dyslipidemia and 87 left eyes from age- and sex-matched participants without dyslipidemia. The retina of dyslipidemia subjects was significantly thinner than that of the controls in the inferior (P=0.004 and P=0.014, respectively) and temporal (P=0.015 and P=0.019, respectively) regions, both inner and outer layers. In terms of blood flow density in the macula or optic disk, there was a decreasing trend in the dyslipidemia group compared with the control group, especially in the inferior and temporal regions. CONCLUSION: Dyslipidemia may contribute to the decrease in retinal thickness and fundus blood flow density. Further validation of the association between abnormal lipid metabolism and fundus microcirculation alterations needs to be carried out in chest pain patients.

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Jin Wang, Yu-Cen Wang, Pei Zhang, et al. Retinal thickness and fundus blood flow density changes in chest pain subjects with dyslipidemia. Int J Ophthalmol, 2023,16(11):1860-1866

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Publication History
  • Received:March 05,2023
  • Revised:August 24,2023
  • Adopted:
  • Online: October 25,2023
  • Published: