Research progress on animal models of corneal epithelial-stromal injury
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Wen Xu. Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China. xuwen2003@aju.edu.cn

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Supported by the National Key Research and Development Program of China (No.2020YFE0204400); the National Natural Science Foundation of China (No.82271042); the Zhejiang Province Key Research and Development Program (No.2023C03090).

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    Abstract:

    A corneal epithelial-stromal defect is recognized as a major contributor to corneal scarring. Given the rising prevalence of blindness caused by corneal scarring, increasing attention has been focused on corneal epithelial-stromal defects. Currently, the etiology and pathogenesis of these defects remain inadequately understood, necessitating further investigation through experimental research. Various modeling methods exist both domestically and internationally, each with distinct adaptive conditions, advantages, and disadvantages. This review primarily aims to summarize the techniques used to establish optimal animal models of corneal epithelial-stromal injury, including mechanical modeling, chemical alkali burns, post-refractive surgery infections, and genetic engineering. The intention is to provide valuable insights for studying the mechanisms underlying corneal epithelial-stromal injury and the development of corresponding therapeutic interventions.

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Li-Rui Liu, Dan Chen, Si-Ting Sheng, et al. Research progress on animal models of corneal epithelial-stromal injury. Int J Ophthalmol, 2023,16(11):1890-1898

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Publication History
  • Received:March 25,2023
  • Revised:August 31,2023
  • Adopted:
  • Online: October 25,2023
  • Published: