Using choroidal thickness to detect myopic macular degeneration
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Ming-Guang He. School of Optometry, the Hong Kong Polytechnic University, Hong Kong SAR, China. mingguang.he@polyu.edu.hk; Zhi-Xi Li. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, China. lzx11-11@163.com

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Supported by the National Natural Science Foundation of China (No.82301249; No.82371086); the Science and Technology Projects in Guangzhou (No.SL2024A04J01756); the Fundamental Research Funds of the State Key Laboratory of Ophthalmology (No.83000-32030003).

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    Abstract:

    AIM: To explore the usage of choroidal thickness measured by swept-source optical coherence tomography (SS-OCT) to detect myopic macular degeneration (MMD) in high myopic participants. METHODS: Participants with bilateral high myopia (≤−6 diopters) were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study. SS-OCT was performed to determine the choroidal thickness, and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia (META-PM) Classification. Presence of MMD was defined as META-PM category 2 or above. RESULTS: A total of 568 right eyes were included for analysis. Eyes with MMD (n=106, 18.7%) were found to have older age, longer axial lengths (AL), higher myopic spherical equivalents (SE), and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector (P<0.001). The area under the receiver operating characteristic (ROC) curves (AUC) for subfoveal choroidal thickness (0.907) was greater than that of the model, including age, AL, and SE at 0.6249, 0.8208, and 0.8205, respectively. The choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD (AUC of 0.928 and 0.923, respectively). An outer nasal sector choroidal thickness of less than 74 µm demonstrated the highest odds of predicting MMD (OR=33.8). CONCLUSION: Choroidal thickness detects the presence of MMD with high agreement, particularly of the inner and outer nasal sectors of the posterior pole, which appears to be a biometric parameter more precise than age, AL, or SE.

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Ran Liu, Meng Xuan, De-Cai Wang, et al. Using choroidal thickness to detect myopic macular degeneration. Int J Ophthalmol, 2024,17(2):317-323

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Publication History
  • Received:July 08,2023
  • Revised:December 20,2023
  • Adopted:
  • Online: January 22,2024
  • Published: