Acute primary angle closure during the Omicron outbreak
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Shao-Chong Zhang. Shenzhen Eye Hospital, Jinan University, Shenzhen Key Ophthalmic Laboratory, 18 Zetian Road, Shenzhen 518040, Guangdong Province, China. zhangshaochong@outlook.com

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Supported by the National Natural Science Foundation of China (No.82301223; No.82271102); the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515111155); the Shenzhen Science and Technology Program (No.KCXFZ20211020163813019); the Shenzhen Science and Technology Program (No.RCBS20210706092347043).

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    Abstract:

    AIM: To investigate Omicron’s impact on clinical presentation of acute primary angle closure (APAC) in China. METHODS: A consecutive case series with historical controls was conducted at Shenzhen Eye Hospital, the largest specialized hospital in Shenzhen, China. Medical records from a two-month period during the Omicron pandemic (December 1, 2022, to January 31, 2023) were compared with records from two control groups (12/2018–1/2019 and 12/2021–1/2022) before pandemic. Patients with APAC were included, and the prevalence of APAC and demographic characteristics in Omicron-infected and non-infected patients were compared. RESULTS: Seventy-one (23.43%) out of 303 patients were diagnosed with APAC in the pandemic cohort, which was 2.98 and 2.61 times higher than that in control cohorts (7.87% in 2019, 8.96% in 2022, P<0.001). The pandemic cohort has significantly higher Omicron-infected rate (78.87% vs 0 vs 0; P<0.001), lower proportion of glaucoma history (16.90% vs 42.86% vs 41.67%, P=0.005), higher surgical rate (95.77% vs 83.33% vs 78.57%, P=0.024), higher total medical costs and larger pupil diameter (5.63±0.15 vs 4.68±0.15 vs 4.69±0.22 mm, P<0.01). In 83% Omicron-infected patients, ocular symptoms appeared within 3d after systemic symptoms onset. In multivariate analysis, Omicron infection (P<0.001) was the only independent predictor of pupil diameter. CONCLUSION: In the Omicron epidemic in China, there is an increase of prevalence and severity of APAC, particularly focusing on the first 3d following infection.

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Dong Fang, Wang-Ting Li, Jia Liang, et al. Acute primary angle closure during the Omicron outbreak. Int J Ophthalmol, 2024,17(7):1337-1343

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Publication History
  • Received:December 19,2023
  • Revised:April 03,2024
  • Adopted:
  • Online: June 25,2024
  • Published: