Prognostic factors for lacrimal gland adenoid cystic carcinoma: a retrospective study in Chinese patients
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Xin Song and Ye-Fei Wang. Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. 40495610@qq.com; paper34@163.com

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Supported by the National Natural Science Foundation of China (No.82303106); Innovative Research Team of High-Level Local Universities in Shanghai (No.SHSMU-ZDCX20210902); the Science and Technology Commission of Shanghai (No.20DZ2270800); Project of Biobank of Shanghai Ninth People’s Hospital (No.ybka202208); 2023 Postdoctoral Research Project Fund of Shanghai Ninth People’s Hospital (No.202401026).

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    Abstract:

    AIM: To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma (LGACC) in Chinese patients. METHODS: Clinical and histopathological data were reviewed in patients with pathologically confirmed LGACC. Local recurrence, metastasis, and disease-specific death were the main outcome measures. Univariate and multivariate analyses were performed by the Kaplan-Meier method and a Cox proportional hazard model. RESULTS: This retrospective cohort study included 45 patients with pathologically confirmed LGACC between January 2008 and June 2022. Tumor (T) classification (P=0.005), nodal metastasis (N) classification (P=0.018) and positive margin (P=0.008) were independent risk factors of recurrence; T (P=0.013) and N (P=0.003) classification and the basaloid tumor type (P=0.032) were independent risk factors for metastasis; T classification (P<0.001) was an independent factor of death of disease. In the further analysis, the durations from first surgery to radiotherapy is correlated with metastatic risk in LGACC patients with basaloid component (P=0.022). CONCLUSION: Histological subtype should be emphasized when evaluating prognosis and guiding treatment. Timely radiotherapy may reduce the risk of metastasis in patients with basaloid component.

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Lu-Di Yang, Shi-Chong Jia, Jie Yang, et al. Prognostic factors for lacrimal gland adenoid cystic carcinoma: a retrospective study in Chinese patients. Int J Ophthalmol, 2024,17(8):1423-1430

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Publication History
  • Received:September 22,2023
  • Revised:March 27,2024
  • Adopted:
  • Online: July 23,2024
  • Published: