目的:评价氯胺酮/甲苯噻嗪麻醉对小鼠晶状体的影响。方法:用氯胺酮(60mg/kg)/甲苯噻嗪(10mg/kg)腹腔注射,分别麻醉4,8,12和16wk的Kimba小鼠(n=10)和野鼠(n=8)。托吡卡胺眼液(25g/L)扩大瞳孔后用HRA+OCT检查晶状体状态和视网膜病变。结果:所有的Kimba小鼠和野鼠都出现严重的眼球突出,眨眼反射消失,角膜干燥和晶状体混浊。最早的晶状体混浊发生在麻醉后的21±6min,晶状体混浊可持续150±24min。结论:氯胺酮/甲苯噻嗪麻醉可导致暂时性晶状体混浊,晶状体混浊与氯胺酮/甲苯噻嗪的副作用有关。

AIM:To assess the affect of ketamine and xylazine (ketamine/xylazine) to the transient lens opacity in mice.METHODS:Kimba mice (n=10) and wild-type mice (wt,n=8) were sedated with intraperitoneal injection of ketamine (60mg/kg for mice) and xylazine (10mg/kg) at 4,8,12 and 16 weeks old respectively. Pupils were dilated with tropicamide 25g/L alone to allow imaging lens status and retina using Spectralis HRA+OCT. RESULTS:All Kimba mice and wt presented extreme proptosis,suppression of the eye-blink reflex,corneal surface drying and lens opacities which occurred as early as 21±6 minutes after giving anesthesia and the lens opacities lasted up to 150±24 minutes.CONCLUSION:Ketamine/xylazine can cause transient lens opacity that may be related with the drugs’ side-effect.

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