目的:评价施图伦滴眼液预防近视患者准分子激光原位角膜磨镶术(laser in situkeratomi leusis,LASIK)术后视疲劳的临床效果。方法:采用前瞻、随机、对照方法,将80例行LASIK手术矫正近视的患者,随机分成两组。40例应用施图伦滴眼液,另40例为对照组。分别于用药前、用药后1,4wk评估患者的症状和体征,同时观察药物不良反应。结果:经重复测量设计方差分析,单眼AMP,AC/A及BUT各观察指标在3个时间点与干预分组(施图伦组与对照组)间无交互作用。施图伦组与对照组间上述各指标均无统计学差异。单眼AMP及BUT术后1wk较术前有一过性下降(P<0.05),随后开始回升,术后4wk与术前无统计学差异。术后1wk裸眼AC/A较术前戴镜的AC/A开始下降(P=0.169),术后4wk仍在下降(P=0.007)。与对照组相比,近读困难、眼胀、头痛、眼干及眩光于术后1wk积分均有上升,但差异无统计学意义。术后4wk施图伦组出现近读困难和眼干的积分较对照组有明显下降,有统计学意义(P<0.05)。但眼胀、头痛及眼干两组积分仍无统计学差异。

AIM:To evaluate the effects of Stulln Mono eye drops on asthenopia after laser in situ keratomileusis(LASIK). METHODS:Eighty consecutive subjects (160 eyes) were divided into two groups randomly (40 in stullen group,and 40 in control group) matched for age and refraction. We analyzed changes in the AC/A,AMP and BUT of single eye. Symptoms were scored according to defined criteria. All patients were evaluated before and one week,four weeks after LASIK surgery. Side effects,if any,were noted during the study. RESULTS:By the repeated measurement,the differences in time interaction effects of AMP,BUT,and AC/A in the two groups were not significant. There was a sudden drop in AMP and BUT(P<0.05) a week after the surgery.Then,AMP and BUT recovered to the pre-operative level. The AC/A ratio of naked eyes was smaller than that of wearing glasses before surgery and 1 week postoperatively.There was no significant difference between the stulln group and the control. Scores of headaches,blurred vision of near work,eye pain,dry eye,glare and halo changed significantly after LASIK. There was no statistical difference between the stulln and the control group in all symptoms a week after LASIK. Scores for blurred vision of nearwork and dry eye reduced four weeks later in Stulln group compared with the control group(P<0.05).CONCLUSION:Stulln Mono eye drops could ameliorate patients’ blurred vision at near work and dry eye four weeks after treatment. 

R779.63

中国湖南省自然基金资助项目(No.08JJ013)~~