AIM:To validate the compliance and efficacy in hospital intensive training by comparing hospital intensive training and family training.METHODS:Outpatients,aging from 3 to 11,diagnosed and sorted according to the standards made by Chinese Medical Association Children Amplyopia and Strabismus Prevention and Cure Group received mydriatic optometry and were remedied refractive error as routine,then randomly united into hospital intensive training group and family training group. We compared the efficacy after fine eyesight training,circular activate machine(CAM) stimalator and pleoptics therapies. The patients were treated for 3-6 months,followed by 2 years. RESULTS:We chose 173 eyes from 100 cases for the hospital intensive training group,of which 136 eyes recovered,33 eyes improved,no efficacy for 7 eyes,the total effective rate was 97.7%. There were 90 eyes from 50 cases for the family training group,of which 35 eyes recovered,37 eyes improved,no efficacy for 18 eyes,the total effective rate was 80.0%. There was significant difference between the two group(P<0.01). (1) Relations between severity and efficacy:the efficacy between the mild and moderate amplyopic subjects of the two groups were both significantly different(P<0.01); The efficacy for the severe amplyopic subjects of the two groups had no significant difference. (2) Relations between different sorts of amplyopia and efficacy:The efficacy of the refractive amplyopia and strabismic amplyopia had significant difference for both groups(P<0.01); There was difference for the anisometropic amplyopia of the two groups(P<0.05),and hospital intensive training group was better. (3) Relations between age and efficacy:There was significant difference for the 3-6 years old subjects and 7-11 years old subjects of the two teams(P<0.05),hospital intensive training had more advantages.CONCLUSION:Given amplyopic severity,sorts and age,hospital intensive training is more effective than family training and has more advantages. It is helpful in improving compliance of amplyopia training.