AIM:To analyze the reason of misdiagnosis and differential diagnosis of acute angle-closure glaucoma in acute episode time in 28 cases.METHODS:Three typical misdiagnosis examples were analyzed.RESULTS:Fifteen cases were misdiagnozed as hyperpie-sia,9 as intracranial hypertension,4 as acute gastroen-teritis,and counteract glaucoma operation was performed in 22 cases after final diagnosis,drug expectant treatment was performed in 6 cases. Vision exceeded 0.5 in 15 cases,hand movement in 2 cases.CONCLUSION:Deficient physician’s cognition to acute angle-closure glaucoma is the main reason for misdia-gnosis. The strengthening of diagnosis consciousness and attaching importance to examination of eyes are the key for avoiding misdiagnosis.